The structural system is not only a carrier of architectural form, but also an important factor in the process of formulating the spatial-functional plan of facilities. Its impact goes far beyond the basic function of ensuring safety of the building. Proper coordination of architectural solutions and structural system allows zone optimization, influences layout arrangement and interiors span and therefore has a strong impact on ergonomics of room solution. Moreover, it allows combining (correct mutual positioning) of the various zones in the building, deployment of special and additional functions (e.g. swimming pools, conference centers, parking lots, etc.). Such interaction is also crucial for matching the hotel facilities to the surrounding environment. Presented article is a summary of research on architecture to structure relation, in pursuit of optimal solutions for maximizing safety and comfort of use in contemporary hotels. The needs of people with impaired physical of psychical conditions were also taken into account.