This chapter examines the use of Cognitive Analytic Therapy (CAT) with men who are experiencing depression. It is argued that since CAT can be seen as a radically interpersonal, humane and transparent psychotherapy which takes as its focus the developmental experiences of an individual and how these may be later unhelpfully and—to begin with—unwittingly re-enacted, CAT can be a particularly useful model to use when working with adult men. By paying careful attention to the therapeutic alliance, we suggest, on the basis of our clinical experience, that CAT can be an excellent vehicle via which many men can come into open, honest contact with previously disavowed feelings, integrating them into their self-understanding—and so take a significant step forward in their recovery.