This chapter starts with a contrast and comparison of Fuller and Latour and a survey of Fuller's criticisms of Latour, on the human and non-human distinction in which Fuller defends that humans have agency against Latour's view that agency is deflated to networks and actants. Next is Fuller's treatment of Kuhn and Popper since Fuller views Kuhn as setting the stage for STS's ascendancy through STS's criticism of normativity in philosophy of science. Fuller's relation to STS to which Fuller is most closely associated is described. Fuller is critical of STS's lack of knowledge policy and of its relativism. STS's version of social constructivism is contrasted to Fuller's realism on the social sciences and social constructivism on the natural sciences.