The paper outlines an overall picture of Agazzi 's philosophical thought and of its coherent development. In fact, in the beginning Agazzi worked on epistemology, and in particular on the philosophy of mathematics. Then he was led to consider science from a more general and systematic point of view. Thus, reflecting on science and its cultural value, Agazzi 's research broadened again its scope, taking into account the links between science, technology and society. But this brought him to analyze the relationships between scientific knowledge and moral reflection. In turn, such a critical survey of the interplay of science and morality required a study of the possible connections between human knowledge and a properly metaphysical dimension. In this last field Agazzi has always referred to the tradition of Western thought, using the method of analogical discourse to construct his metaphysical discourse. Finally, Agazzi has just published a book devoted to the problem of the objectivity of science, but more in general of human knowledge: a work which rounds up his reflection, highlighting its internal coherence and critical potentialities.