This paper aims at developing a mobile pills framework in the electronic healthcare by using mobile information technologies. Specifically, an electronic based framework is developed to show how to mobile information technology and information system can be adopted in mobile pills. Then, a set of usability solution items are developed based on this framework. A prototype was created to show the real implementation of an m-pill system with these important features. The findings from this paper will be helpful to managers when making decisions on m-pills development.