Virtue is connected with wisdom as early as in ancient Greece. Wisdom is looked as one of the four main virtues and virtue is required by wisdom. The ancient Greek enlightens us to explore the relationship between virtue and wisdom in our research of virtue. In this sense, we hold that wisdom has decisive effect in the process of virtue formation and the action of virtue calls for the participation of wisdom. The relation between virtue and wisdom is very complicated. The paper will mainly discuss the mutuality of the two concepts.