This review aims to be a pragmatic primer in the field of post-genomic bioremediation of NACs-based explosives with special emphasis on the "omics" technologies. After an introduction in the concepts and methodologies of high-throughput molecular approaches and a discussion of the numerous emerging variations on the basic theme, a short overview of the success stories of "omics" in bioremediation of NACs are revisited, followed by a brief discussion about the technical, methodological, and computational resources that embody the landscape of microbial epimetabolome. The review ends with a note on the research-commercialization gap, taking into account the containment technologies pertaining to biosafety issues and technical safeguards.