This introductory chapter provides a model for interdisciplinary, place-based learning in urban settings and virtual worlds. It explores how place-based learning can be implemented successfully through the lens of general education and through interdisciplinary courses that effectively use this pedagogical strategy at New York City College of Technology (City Tech). This chapter also covers pedagogical strategies for teams of teachers, as well as games for learning. Methods and examples of interdisciplinary studies that link seemingly disparate domains, including educational technology (e.g., role-playing games and simulations), are highlighted.