This chapter builds on the first five chapters in this handbook that explained the research design typology. The focus here is on establishing rationale and significance of research. This chapter is intended to serve as a guide for practitioners to apply and integrate the research design typology layers into a scholarly manuscript. In contrast to the broad scope of the first five chapters, this chapter concentrates on how to integrate specific components of the typology regardless of which ideology the researcher holds on the continuum (positivist, post-positivist, pragmatist, interpretivist, or constructivist).