An account is offered of Dooyeweerd's non-reductionist ontology. It also includes the role of religious belief in theory making, although it omits his case for why such a role is unavoidable. The ontology is a theory of the nature of (created) reality which presupposes and is regulated by belief in the God of Judeo-Christian theism. Because it takes everything in creation to be directly dependent on God, it offers an account of the natures of both natural things and artifacts which avoids regarding anything in the cosmos as what all else in the cosmos depends on.