The mental system of an individual usually generates a reality-model that includes a self-model and a world-model as fundamental components. Exceptional experiences (ExE) can be classified as subjectively experienced anomalies in the self-model or the world-model or in the relation of both. Empirical studies show significant correlations between specific patterns of ExE and socially and clinically relevant variables. In order to examine the ontological status of anomalous phenomena a psychophysical approach is presented in which the principle of complementarity is of fundamental importance. Applying a generalized quantum theory to psychosocial and psychophysical systems, complementary aspects such as autonomy versus reliability or novelty versus confirmation are identified as possible local and global variables. The findings indicate that entanglement correlations could play a role in the occurrence of ExE and that specific psychological interventions can dissolve them.